肠屏障功能障碍是导致全身炎性反应综合征、多器官功能障碍综合征甚至多器官功能衰竭的一个重要因素。在饥饿、创伤、感染等应激状态下,肠屏障功能发生一系列的病理生理改变,导致肠黏膜细胞萎缩、通透性增加、肠道细菌移位。本文综述了影响肠屏障功能的因素,引起肠屏障功能损伤的机制及合理的营养支持途径、谷氨酰胺、生长激素及多肽类生长因子等因素对肠屏障功能的保护作用。 Gut barrier dysfunction is an important factor that leads to systemic inflammatory response syndrome, multiple organ dysfunction syndrome and even multiple organ failure. In starvation, trauma, infection and other stress conditions, a series of pathophysiological changes in intestinal barrier function, leading to intestinal mucosal atrophy, increased permeability, intestinal bacterial translocation. This article reviews the factors that affect the intestinal barrier function, the mechanism of causing intestinal barrier function damage and reasonable nutritional support, glutamine, growth hormone and peptide growth factor and other factors on the protective function of intestinal barrier.