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为探讨前列环酸（ＰＧＩ２）和血栓素（ＴＸＡ２）与先兆早产的关系，采用放射免疫法分别测定了先兆早产和足月临产孕妇血及宫颈粘液中６－酮－ＰＧＦ１α、ＴＸＢ２和孕酮的浓度，并与相对应孕周的孕妇进行比较。结果：与对照组相比，先兆早产组及足月临产组的血浆ＴＸＢ２和６－酮－ＰＧＦ１α水平明显升高（Ｐ＜０．００１），６－酮－ＰＧＦ１α／ＴＸＢ２比值降低（Ｐ＜０．００１），而孕酮水平则无显著性差异（Ｐ＞０．０５）；粘液中的结果与血一致。由此提示：ＰＧＩ２、ＴＸＡ２和ＰＧＩ２／ＴＸＡ２比值（ＴＸＡ２升高得更多）与先兆早产和足月临产的发生有关。先兆早产和足月临产之孕酮水平与对照组无差异，孕酮局部的撤退或下降可能在生产的发动中起作用。
To investigate the relationship between prostacycline (PGI2) and thromboxane (TXA2) and threatened preterm labor, radioimmunoassay was used to determine the levels of 6-keto-PGF1α, TXB2 and progesterone in blood and cervical mucus of threatened preterm and term pregnant women Concentration, and with the gestational age corresponding pregnant women were compared. Results: Compared with the control group, the levels of plasma TXB2 and 6-keto-PGF1α were significantly increased (P <0.001) and the ratio of 6-keto-PGF1α / TXB2 decreased .001), while there was no significant difference in progesterone levels (P> 0.05); the results in mucus were consistent with those in blood. This suggests that: PGI2, TXA2 and PGI2 / TXA2 ratio (TXA2 increased more) and threatened preterm birth and full-term labor related to the occurrence. Progesterone preterm labor and full-term labor of progesterone levels were no different from the control group, local withdrawal or decline of progesterone may play a role in the onset of production.