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本工作研究了大黄对HCl产生的大鼠胃粘膜损伤的影响,结果表明,10%的大黄煎剂可明显减轻由0.6N HCl产生的胃粘膜坏死性损伤,并且这一作用可被消炎痛所取消。表明大黄对大鼠胃粘膜的这种保护作用系通过刺激胃内前列腺素合成实现的。
This work investigated the effects of rhubarb on gastric mucosal lesions in rats exposed to HCl. The results showed that 10% rhubarb decoction significantly reduced the necrosis of the gastric mucosa caused by 0.6N HCl, and this effect can be induced by indomethacin. cancel. This shows that the protective effect of rhubarb on gastric mucosa in rats is achieved by stimulating prostaglandin synthesis in the stomach.