心房纤颤(简称房颤)是临床最常见的心律失常之一,其最严重的临床表现是血栓栓塞及心功能恶化。在风湿性心脏瓣膜病中房颤的发生率可达40%~50%,二尖瓣病高于主动脉瓣病,二尖瓣关闭不全高于二尖瓣狭窄[1]。关于房颤发生的机制涉及的两个主要问题是发生房颤的基质和诱发房颤的因素 Atrial fibrillation (atrial fibrillation) is one of the most common clinical arrhythmias, and its most serious clinical manifestations are thromboembolism and deterioration of cardiac function. In rheumatic heart disease, the incidence of atrial fibrillation can reach 40% to 50%, mitral valve disease is higher than aortic valve disease, mitral regurgitation is higher than mitral stenosis [1]. The two major issues involved in the mechanism of atrial fibrillation are the substrate for the occurrence of atrial fibrillation and the factors that cause atrial fibrillation