增殖性糖尿病视网膜病变(PDR)是糖尿病最常见的并发症之一,已成为目前世界范围内主要致盲眼病,引起人们越来越多的关注[1]。目前PDR的发病机制尚未完全明了,缺血、缺氧是因素之一,另外多种细胞生长因子在PDR的发生发展中起到的作用已经被大家所认识。其中瘦素是最近发现的在眼 Proliferative diabetic retinopathy (PDR) is one of the most common complications of diabetes, which has become the major cause of blindness in the world and attracts more and more attention [1]. At present, the pathogenesis of PDR is not yet completely understood. Ischemia and hypoxia are one of the factors. In addition, the role of many kinds of cell growth factors in the development of PDR has been recognized. Leptin is the most recently discovered in the eye