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目的:随访H型高血压患者脑梗死后口服叶酸片后缺血性脑血管病的复发率,为H型高血压患者缺血性中风的二级预防提供依据。方法:选取2010-2014年本院神经内科伴有H型高血压脑梗死住院患者共598例,所有患者在脑梗死二级预防基础治疗上均加服依那普利叶酸片。随访患者2年,观察缺血性脑血管病、冠脉事件、周围血管事件、抑郁、痴呆、骨折、肿瘤的发病率及死亡率。结果:598例脑梗死患者中,失访70例,到达终点患者共528例。脑梗死复发18例,冠脉事件23例,周围血管事件15例,抑郁患者95例,痴呆患者38例。无骨折发生,无新发肿瘤患者,死亡14例。结论:服用依那普利叶酸片后脑梗死患者复发率3.41%,冠脉事件的发生率4.36%,周围血管事件发生率2.85%,抑郁的发生率8.52%,痴呆的发生率7.20%。服用依那普利叶酸片后脑梗死复发率明显降低,未增加肿瘤的发生率。
OBJECTIVE: To investigate the recurrence rate of ischemic cerebrovascular disease after oral administration of folic acid tablets in patients with Hypertension and to provide evidence for the secondary prevention of ischemic stroke in patients with Hypertension. Methods: A total of 598 hospitalized patients with Hypertensive cerebral infarction in our hospital from 2010 to 2014 were enrolled. All patients were given enalapril folate tablets in the secondary prevention of cerebral infarction. Patients were followed up for 2 years to observe the incidence of ischemic cerebrovascular disease, coronary events, peripheral vascular events, depression, dementia, fracture, tumor incidence and mortality. Results: Among the 598 patients with cerebral infarction, 70 patients were lost to follow-up, and 528 patients reached the end point. Recurrence of cerebral infarction in 18 cases, 23 cases of coronary events, peripheral vascular events in 15 cases, 95 cases of depression, 38 cases of dementia. No fracture occurred, no new tumor patients, 14 patients died. Conclusion: The recurrence rate of cerebral infarction patients after enalapril treatment is 3.41%. The incidence of coronary events is 4.36%. The incidence of peripheral vascular events is 2.85%. The incidence of depression is 8.52%. The incidence of dementia is 7.20%. After taking enalapril folate tablets significantly reduced the recurrence rate of cerebral infarction, did not increase the incidence of cancer.