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每日给予雌性大鼠口服雷公藤总甙每天TⅡ或TG30mg/kg共35天及80天,性动周期由正常转为不规则。卵巢形态大致正常。子宫减重,光镜下见部分肌层及肌纤维束稍变薄变细;由镜下见子宫内膜腺体细胞细胞器显著减少及平滑肌细胞溶酶体增加。血浆雌二醇及孕酮水平无改变,在同等实验条件下,药物对雌鼠生殖系统的影响远较雄鼠为轻。
Female rats given daily oral TII or TG30mg / kg oral total 35 days and 80 days, the sexual movement cycle from normal to irregular. Ovary morphology is generally normal. Uterine weight loss, see the light microscope, part of the muscle and muscle fiber bundles slightly thinner and thinner; see the endometrial gland cells organelles significantly reduced and smooth muscle cell lysosome increased. Plasma estradiol and progesterone levels did not change, under the same experimental conditions, the impact of drugs on female reproductive system far lighter than male rats.