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目的探讨胚胎停育患者在生活和工作中接触环境的危险因素。方法采用病例-对照研究,于2008年7月1日—2009年5月1日北京市某区妇幼保健院进行问卷调查,了解个人基本情况、环境中接触到的可疑的危险因素、生殖保健知识、婚检等情况。选择253例确诊的胚胎停育孕妇为病例组,同期239例正常妊娠者为对照。结果非条件Logistic回归分析表明工作场所、家庭通风情况(OR=0.514),孕早期使用手机、电脑的时间(OR=2.266),月经量(OR=-1.552),孕前、孕期获得生殖保健服务(OR=-1.384),急性感染(OR=2.074)可能与胚胎停育的发生有关。结论孕妇居室通风,孕前、孕期获得生殖保健服务,婚检可能是预防胚胎停育的保护性因素,孕期使用手机、电脑,妊娠前3个月急性感染可能是胚胎停育发生的危险因素。
Objective To investigate the risk factors of environmental exposure in living and working of patients with embryo stop. Methods A case-control study was conducted from July 1, 2008 to May 1, 2009 in a district of MCH in Beijing to investigate the basic conditions of individuals, suspicious risk factors exposed to the environment, reproductive health knowledge , Premarital and other conditions. A total of 253 pregnant women with confirmed pregnancy were selected as the case group and 239 normal pregnant women as controls. Results Non-conditional Logistic regression analysis showed that the workplace and family ventilation (OR = 0.514), the use of mobile phones and computers in early pregnancy (OR = 2.266), menstrual flow (OR = -1.552), reproductive health services before and during pregnancy OR = -1.384). Acute infection (OR = 2.074) may be related to the occurrence of embryo stop. Conclusions Pregnant women have adequate ventilation in their rooms, reproductive health services before pregnancy and during pregnancy. Premarital examination may be a protective factor in preventing embryo suspension. Using a mobile phone or a computer during pregnancy, acute infection during the first 3 months of pregnancy may be a risk factor for embryo shutdown.