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新疆雪莲(Saussurea involucrate kar etkin. ex Maxim)为菊科青木香属植物,经化学成分预试含有黄酮、生物碱、内酯、甾醇、挥发油和还原糖等。其中总黄酮和总生物碱具有消炎、镇痛作用。乌鲁木齐中药厂研制的雪莲注射液,经动物实验证明,具有抗炎镇痛作用,且毒性小(LD_(50)=18.8g/kg)。临床观察497例患者,对风湿或类风湿性关节炎、风寒性腰腿痛等总有效率达88％。本文对雪莲注射液进行了兔体内药代动力学研究,探讨其体内动态经时过程,为制定质量标准,
Saussurea involucrate kar etkin. ex Maxim is a genus Asteraceae of Asteraceae. It has been chemically tested to contain flavonoids, alkaloids, lactones, sterols, volatile oils, and reducing sugars. Total flavonoids and total alkaloids have anti-inflammatory and analgesic effects. Xuelian injection developed by Urumqi Chinese Medicine Factory has been proved by animal experiments that it has anti-inflammatory and analgesic effects and has low toxicity (LD_(50)=18.8g/kg). Clinical observation of 497 patients had a total effective rate of 88% for rheumatism or rheumatoid arthritis, cold-backed leg and leg pain. In this paper, the in vivo pharmacokinetics of saussurea japonica was studied in rabbits to explore its dynamic in vivo process and to establish quality standards.