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安定（地西泮）是治疗各种原因所致癫痫特持续状态的最佳药物之一，常用剂量 ２ｍｇ／ｍｉｎ（老年人 １ｍｇ／ｍｉｎ）静脉注射，直至发作停止或总量达２０—３０ｍｇ，半小时后如未控制发作，可再追加１０ｍｇ；儿童用量为０．３—０．５ｍｇ／ｋｇ（如无法估计体重则每岁１ｍｇ，另再加１ｍｇ，即４岁儿童用５ｍｇ，余类推）。也曾有报告首列静脉推注２０ｍｇ安定，无效时改用静脉滴注，每小时进１０ｍｇ（在５ｍｉｎ左右滴进，间歇期用其他液体维持）日总量达２４０ｍｇ，治疗难治性癫痫状态获得成功。但安定持续静脉滴注、特别是大剂量滴注或推注应极端谨慎小心，因为安定的主要不良反应为呼吸衰竭，低血压和心脏骤停，如已有呼吸功能损害时或推注速度太快时可以引起特异反应性呼吸停止。本文作者用大剂量安定治疗破伤风抽搐的经验仅供参考和争鸣，欢迎广大读者来稿讨论。
Diazepam (diazepam) is one of the best drugs for treating persistent state of epilepsy due to various reasons. The usual dose of 2mg / min (1mg / min for the elderly) is injected intravenously until the seizures stop or the total amount reaches 20-30mg, Half an hour later, if uncontrolled seizures, additional 10mg; children in the amount of 0.3-0.5mg / kg (if you can not estimate the weight of 1mg per year, plus 1mg, that is, 4-year-old children with 5mg, and so on) . It has also been reported that the first intravenous bolus 20mg diazepam, ineffective switch to intravenous drip, per hour into the 10mg (drip about 5min, intermittent use of other liquids to maintain) the total amount of 240mg, the treatment of refractory epilepsy Success. However, continuous intravenous infusion of diazepam, especially high-dose instillation or bolus should be extremely cautious, because the main adverse events of diazepam are respiratory failure, hypotension and cardiac arrest, such as respiratory dysfunction or have been impaired too fast Fast can cause specific reactive respiratory arrest. The author of high-dose stability treatment of tetanus convulsions for reference only and contention, readers are welcome to discuss the manuscript.