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我们从临床角度探讨一氧化氮(NO)、内皮素(ET)与肝肾综合征(HRS)发生的关系,为防治肝硬变并发症提供切实的理论依据。 1 材料和方法 1.1 材料 肝硬变患者55例,其中肝硬变无HRS 30例,肝硬变合并HRS25例,健康成年人22例为对照组,年龄、性别构成与观察组差异无显著性,诊断符合95年北京第5次全国传染病及寄生虫病会议修订的病毒性肝炎防治方案。 1.2 方法 NO测定利用硝酸盐还原酶法测定,ET,TNF均采用放射免疫法测定,试剂盒均购自解放军总医院放免研究所。 统计学处理 方差分析 相关分析t检验。
We explore the relationship between nitric oxide (NO), endothelin (ET) and hepatorenal syndrome (HRS) from a clinical point of view and provide a theoretical basis for the prevention and treatment of complications of liver cirrhosis. 1 Materials and Methods 1.1 Materials 55 patients with cirrhosis, including cirrhosis without HRS 30 cases, cirrhosis with HRS 25 cases, healthy adults 22 cases as control group, age, gender and observation group no significant difference, Diagnosis in line with the 95th Beijing Fifth National Infectious Diseases and Parasitic Diseases meeting revised viral hepatitis prevention and treatment programs. 1.2 Methods NO Determination Determination of nitrate reductase, ET, TNF were determined by radioimmunoassay, kits were purchased from the People’s Liberation Army General Hospital Radiation Institute. Statistical analysis of variance analysis correlation analysis t test.