为分析上海地区汉族人HLA DQB1启动子 (QBP )多态性 ,以及QBP与DQB1的连锁不平衡 ,我们选用 2 4个序列特异性寡核苷酸探针 (SSO )检测QBP多态性。在目前已知的 12种QBP等位基因中 ,我们仅检测到 10种 (未发现新的QBP类型 ) ,并且发现QBP与DQB1的某些等位基因之间存在一定的连锁格局。我们的结果与高加索人群研究结果比较发现 ,无论是QBP基因频率还是QBP DQB1单元型频率 ,在两种不同人群中都存在明显差异。结果提示 ,由于不同的QBP等位基因功能不同 ,因此QBP DQB1之间不同的单倍型组合可能是HLA与疾病关联的另一个因素。 To analyze the polymorphism of HLA DQB1 promoter (QBP) and linkage disequilibrium between QBP and DQB1 in Shanghai Han population, we selected 24 sequence-specific oligonucleotide probes (SSO) to detect QBP polymorphism. Of the 12 known QBP alleles we detected only 10 (no new QBP type was found) and found a linkage pattern between QBP and some alleles of DQB1. Our results compared with the Caucasians study found that there was a significant difference between the two populations for either the QBP gene frequency or the QBP DQB1 haplotype frequency. The results suggest that different haplotype combinations between QBP DQB1 may be another factor linked to disease due to the different function of different QBP alleles.