本文观察了蒿甲醚实验治疗小鼠血吸虫病时,其体内血吸虫及宿主肝脏的组织学与组织化学改变。发现蒿甲醚不仅能引起肝移虫的体表、肠管及生殖器官等明显退化变性,而且具有明显的杀血吸虫成虫作用,其杀雌虫作用尤为迅速和强烈。该药可使肝移虫体的糖原,碱性磷酸酶,RNA及酚酶明显减少或消失;雌虫出现这些变化较雄虫为早。同时,蒿甲醚可引起小鼠肝细胞水样变性,肝脏糖原、碱性磷酸酶及RNA明显减少甚至消失。 This article observed the artemether experimental treatment of schistosomiasis in mice, the body of schistosomes and host liver histological and histochemical changes. It was found that artemether could not only cause obvious degeneration and degeneration of body surface, intestine and reproductive organs, but also had obvious schistosomiasis killing effect. The killing effect on female was particularly rapid and intense. The drug can cause liver worms body glycogen, alkaline phosphatase, RNA and phenolic enzymes significantly reduced or disappeared; females appear these changes earlier than the male. At the same time, artemether can cause watery degeneration of mouse hepatocytes, liver glycogen, alkaline phosphatase and RNA significantly reduced or even disappeared.