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目的 探讨类胰岛素生长因子 (insulin likegrowthfactor 1,IGF 1)与胎儿生长发育的关系。 方法 对 38例正常儿、2 0例母体糖尿病新生儿和 15例巨大儿的足月分娩前母血及脐血进行IGF 1测定 ,明确IGF 1与新生儿体重和身长的关系。结果 正常足月分娩的脐血IGF 1值平均为 70 μg/L ,脐血IGF 1和新生儿体重和身长均呈正相关。母血IGF 1是脐血IGF 1的 2 87倍 ,母血IGF 1和脐血IGF 1呈明显正相关。糖尿病组母血和脐血的IGF 1均高于正常组 ,巨大儿组的母血IGF 1高于正常组。结论 IGF 1是促进胎儿生长发育的一种细胞因子。孕期母血IGF 1监测可以预测胎儿生长发育情况。
Objective To investigate the relationship between insulin like growth factor 1 (IGF1) and fetal growth and development. Methods IGF 1 was measured in maternal blood and umbilical cord blood of 38 normal children, 20 newborn infants with maternal diabetes and 15 giant maternal children before delivery. The relationship between IGF 1 and body weight and body length of neonates was determined. Results The average IGF1 value of umbilical cord blood in normal term delivery was 70 μg / L, and IGF1 in umbilical cord blood was positively correlated with body weight and length of neonates. The maternal serum IGF1 was 287 times that of umbilical cord blood IGF1, and the maternal serum IGF1 was positively correlated with cord blood IGF1. IGF1 in maternal and umbilical blood was higher in diabetic group than in normal group, while maternal serum IGF1 in macro-group was higher than that in normal group. Conclusion IGF 1 is a cytokine that promotes fetal growth and development. Maternal and fetal IGF 1 monitoring during pregnancy can predict fetal growth and development.