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目的 探讨不同剂量醋酸甲羟孕酮 (DMPA)用于哺乳期妇女避孕对其避孕效果、副反应发生率及停用原因的影响。方法 将受试对象按剂量随机分为 12 0mg和 15 0mg两组 ,排除不符合研究标准者 ,纳入研究对象共计 173例 ,12 0mg组 87例 ,15 0mg组 86例。每 3个月深部肌肉注射 1次 ,共 4次。 结果 两组避孕成功率均为 10 0 0 0 % ;发生副反应中 ,点滴出血 12 0mg组为 6 90 % ,明显低于 15 0mg组的 16 2 8% (P <0 0 5 )。结论 12 0mgDMPA用于哺乳期妇女避孕不影响其有效性 ,且可减少副反应发生率。
Objective To investigate the effects of different doses of medroxyprogesterone acetate (DMPA) on contraceptive effectiveness, incidence of side effects and the causes of discontinuation in lactating women. Methods Subjects were randomly divided into two groups according to the dose of 12 0mg and 150 mg, excluding those who did not meet the research criteria. A total of 173 subjects were enrolled in the study, including 87 cases in 120 mg group and 86 cases in 150 mg group. Deep muscle injection every 3 months, a total of 4 times. Results The success rate of contraception in both groups was 100%. In side effects, the bleeding volume in 120 mg group was 6 90%, which was significantly lower than that in 15 0 mg group (P <0.05). CONCLUSION: Contraceptive use with 12 mg of DMPA for breast-feeding women does not affect their effectiveness and may reduce the incidence of side effects.