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目的:评估VIP方案化疗与放射治疗晚期非小细胞肺癌(NSCLC)的近期疗效。方法:观察1997年2月～1999年2月收治的33例晚期非小细胞肺癌患者。化疗以VIP方案为主,2～4周期后行放射治疗,放疗剂量DT 50～70Gy/5～7周。结果:完全缓解(CR)率为15.2％,部分缓解率(PR)为51.5％,总有效率(CR+PR)为66.7％。毒副反应主要为Ⅰ～Ⅱ度消化道反应、骨髓抑制及脱发。结论:VIP方案化疗加放疗治疗晚期非小细胞肺癌的近期疗效较为满意,毒副反应患者可以耐受。
Objective: To evaluate the short-term efficacy of VIP regimen chemotherapy and radiotherapy for advanced non-small cell lung cancer (NSCLC). Methods: From February 1997 to February 1999, 33 patients with advanced non-small cell lung cancer were observed. Chemotherapy with VIP-based program, 2 to 4 cycles after radiotherapy, radiation dose DT 50 ~ 70Gy / 5 ~ 7 weeks. Results: The complete remission (CR) rate was 15.2%, the partial remission rate (PR) was 51.5% and the total effective rate (CR + PR) was 66.7%. Toxicity mainly Ⅰ ~ Ⅱ degree digestive tract reaction, bone marrow suppression and hair loss. Conclusions: The short-term curative effect of VIP regimen combined with radiotherapy in the treatment of advanced non-small cell lung cancer is satisfactory, and patients with toxic side effects can tolerate it.