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来自生物系统产生的O_2自由基都会由歧化反应生成H_2O_2。H_2O_2是弱氧化剂,可以通过氧化巯基(SH)使少数酶灭活,培养的动物细胞(如人成纤细胞)在加入微克分子水平时即受损伤。这是由于过氧化氢可以迅速穿透细胞膜的缘故,进入细胞的H_2O_2可与Fe~(2+)或Cu~+起反应生成OH自由基,这是H_2O_2的毒性所在。潘华珍等(1984)报导用红细胞在体外与过氧化氢反应产生脂质过氧化产物-丙二醛(MDA)并导致与磷脂及蛋白质交联,使
O 2 radicals produced by biological systems will generate H 2 O 2 from disproportionation reaction. H 2 O 2 is a weak oxidant that can inactivate a few enzymes through the oxidation of thiol (SH), and cultured animal cells (such as human fibroblasts) are damaged at the micromolar level. This is due to hydrogen peroxide can quickly penetrate the cell membrane sake into the cell H_2O_2 can react with Fe ~ (2+) or Cu ~ + to generate OH radicals, which is H_2O_2 toxicity. Pan et al. (1984) reported that red blood cells react with hydrogen peroxide in vitro to produce the lipid peroxidation product, malondialdehyde (MDA), and result in cross-linking with phospholipids and proteins