例1,女,40岁,因患子宫颈管肌瘤,行子宫全切术,术后22个月,出现尿频、阴道粘膜干燥.伴头晕目眩、烦燥不安、思想不集中、多汗等.因而1次顿服尼尔雌醇片剂(Tabllae Nilestrioli)2.5mg.1周后,全身皮肤颜色变深,尤以面部为甚,呈均匀状分布.停药后,全身及面部色素渐褪,变淡、恢复原状. Case 1, female, 40 years old, suffering from cervical cancer, uterine total hysterectomy, 22 months after surgery, frequent urination, dry vaginal mucosa with dizziness, irritability, lack of concentration, sweating, etc. Thus, after 1 tablet of Tabllae Nilestriol (2.5 mg) for 1 week, the skin of the whole body became darker, especially in the face with a uniform distribution. After stopping, the whole body and facial pigment gradually faded , Fades, restores.