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目的 研究选择性血管紧张素II受体 1拮抗剂 (AR1B)对心肌梗死 (MI)后心肌胶原重构的影响。方法 新西兰大白兔心梗后随机分组用valsartan治疗 (V组 )或不治疗 (C组 ) ,并设假手术组 (S组 )。治疗 10周后测量血流动力学参数、胶原含量。结果 MI后 10周C组梗死区和非梗死区胶原含量明显高于S组 ;V组中上述指标显著下降 ,但仍高于S组。非梗死区胶原含量与左室舒张末压呈明显正相关。结论 (1)在家兔心梗后早期应用Valsartan能改善血流动力学、抑制心肌纤维化 ;(2 )非梗死区胶原沉积是降低心功能的主要因素之一。非梗死区胶原含量与左室舒张末压有明显相关性。
Objective To investigate the effect of selective angiotensin II receptor 1 antagonist (AR1B) on myocardial collagen remodeling after myocardial infarction (MI). Methods New Zealand white rabbits were randomly divided into two groups: valsartan group (group V) or no treatment group (group C), and sham operation group (group S). After 10 weeks of treatment, hemodynamic parameters and collagen content were measured. Results The content of collagen in infarction area and non-infarction area in group C at 10 weeks after MI was significantly higher than that in group S; the above indexes in group V were significantly decreased, but still higher than those in group S. Non-infarct collagen content and left ventricular end diastolic pressure was positively correlated. Conclusions (1) Valsartan can improve hemodynamics and inhibit myocardial fibrosis in rabbits after myocardial infarction. (2) Collagen deposition in non-infarct area is one of the main factors to reduce cardiac function. Non-infarct collagen content and left ventricular end-diastolic pressure were significantly correlated.