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慢性乙型肝炎是一种严重危害人类健康的传染性疾病,在全球有多达3.6亿人感染上慢性乙型肝炎病毒,我国约占1.2亿人。近几年来,拉米夫定作为一种新的核苷类似物广泛被医患接受,是目前临床应用中疗效较好的,具有代表性的核苷类似物。它的作用机制为抑制病毒DNA多聚酶和逆转录酶活性,并对病毒DNA链的合成和延长有竞争性抑制作用。
Chronic hepatitis B is a contagious disease that seriously endangers human health. As many as 360 million people worldwide are infected with chronic hepatitis B virus, and China accounts for about 120 million people. In recent years, lamivudine as a new nucleoside analogues widely accepted by doctors, is currently the clinical efficacy of good, representative nucleoside analogues. Its mechanism of action is to inhibit the activity of viral DNA polymerase and reverse transcriptase, and competitive inhibition of viral DNA chain synthesis and elongation.