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慢性肾脏疾病的(CKD)近几年明显呈增长趋势,本病终末期会发展至尿毒症,从而给社会、家庭、患者带来沉重负担。因此,减少尿毒症发生,降低医疗费用,是必须面对和解决的问题。无论何种慢性肾疾病,最终共同的病变,均表现为肾小球硬化和肾小管间质纤维化,从而导致慢性肾衰竭,而在疾病发生发展的病理过程中,由内皮素(ET)、肌钙蛋白等多种细胞因子形成相互作用的调控网,及病理过程中的恶性循环,共同参与整个的病理过程。而ET-1、c-Tn和胱抑素-C水平的变化对于诊断慢性肾脏疾病具有重要的临床意义。
Chronic kidney disease (CKD) showed a clear upward trend in recent years, the disease will eventually develop to uremia, which will bring a heavy burden on society, families and patients. Therefore, to reduce the occurrence of uremia, reduce medical costs, is the problem must be addressed. No matter what kind of chronic kidney disease, the final common lesion, are manifested as glomerulosclerosis and tubulointerstitial fibrosis, leading to chronic renal failure, and in the pathological process of disease development, by the endothelin (ET), Troponin and other cytokines to form a regulatory network of interaction, and the vicious cycle of pathological processes, to participate in the entire pathological process. Changes in the levels of ET-1, c-Tn and cystatin-C have important clinical implications for the diagnosis of chronic kidney disease.