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本研究通过采用放免法测定血浆内皮素（ＥＴ）水平，探讨血浆ＥＴ在慢性肾功能不全发病中的意义。研究对象分４组：尿毒症组、氮质血症组、患各种肾疾病但肾功能正常组和正常对照组。同时监测其ＢＵＮ，血压水平。发现血ＥＴ在尿毒症组和氮质血症组较正常对照组明显升高（Ｐ＜０．００１），也较患有肾病但肾功能正常组高（Ｐ＜０．００１）。并且在慢性肾功能不全时血浆ＥＴ和ＢＵＮ及ＢＰ呈正相关关系（ｒ＝０．６３３，Ｐ＝０．００１；ｒ＝０．６１２，Ｐ＝０．００１）。研究结果提示ＥＴ可能在慢性肾功能不全发病中起一定的作用。
In this study, the level of plasma endothelin (ET) was determined by radioimmunoassay to explore the significance of plasma ET in the pathogenesis of chronic renal insufficiency. Subjects were divided into 4 groups: uremia group, azotemia group, suffering from various renal diseases but normal renal function group and normal control group. At the same time monitoring its BUN, blood pressure levels. ET was found to be significantly elevated (P <0.001) in uremia and azotemia groups compared with normal controls, but also higher than in nephrotic patients with normal renal function (P <0.001). And in chronic renal failure plasma ET and BUN and BP was positively correlated (r = 0.633, P = 0.001; r = 0.612, P = 0.001). The results suggest that ET may play a role in the pathogenesis of chronic renal failure.