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绒毛膜促性腺激素hCG是妊娠滋养细胞疾患(GTD)理想的肿瘤标志,对GTD的诊断和治疗都具有特殊意义。有学者[1]认为自50年代以来GTD治愈率骤然上升,有三个原因:①GTD对化疗制剂固有的敏感性;②GTD有敏感的hCG标记;③一些高危因素的发现以及有针对性的处理。近年来由于生物化学、分子生物学、放射免疫测定、放射受体测定、单克隆抗体制备、激素免疫荧光测定以及电子显微镜等科学技术的发展,对hCG的分泌部位、分子结构、氨基酸排列和生物学及免疫学性能有了进一步认识。本文主要概述hCG对GTD诊断和治疗的意义。一、hCG在葡葡胎诊断与治疗上的意义葡萄胎病人外周血hCG水平比相同孕期的正常妊娠要高,所以怀疑为葡萄胎的病人应该检查hCG。但是葡萄胎与正常妊娠hCG水平并无明确界限。正常妊
Human chorionic gonadotropin (hCG) is an ideal tumor marker for gestational trophoblastic disorders (GTD) and has special significance for the diagnosis and treatment of GTD. Some scholars [1] think that since the 1950s GTD cure rate increased suddenly for three reasons: ① GTD sensitivity of chemotherapy inherent; ② GTD sensitive hCG markers; ③ some of the risk factors found and targeted treatment. In recent years due to biochemistry, molecular biology, radioimmunoassay, radioactive receptor determination, monoclonal antibody preparation, hormone immunofluorescence and electron microscopy and other scientific and technological development, the hCG secretion site, molecular structure, amino acid alignment and biological Learning and immunology performance have been further understanding. This article summarizes the significance of hCG diagnosis and treatment of GTD. First, the significance of hCG in the diagnosis and treatment of Portuguese children TCD patients with peripheral blood hCG levels higher than the same normal pregnancy, so suspected patients with hydatidiform mole should check hCG. However, there is no clear boundary between hydatidiform mole and normal pregnancy hCG level. Normal pregnancy