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本文观察黄连素(10mg/1)对豚鼠心室乳头肌快反应AP的作用,以及在用异搏定,心得安分别阻断钙通道或β-受体后,黄连素对心室乳头肌快反应AP作用的改变。结果证明黄连素(10mg/1)对快反应AP的时程有明显的延长作用(APD_(20)增加22.90％、APD_(50)增加16.56％、APD_(90)增加13.31％)。然而,在异搏定或心得安预先作用下,上述的黄连素增宽快反应AP的时程作用完全消失,但是个别例子中APD_(90)仍有增宽。上述结果提示,黄连素的增宽APD作用主要是通过兴奋β-受体后促进了钙离子内流,最后表现为快反应AP的时程增宽。另外,黄连素对钾离子外流可能也有一定的抑制作用。黄连素在1—10mg/1浓度范围内对时间·强度曲线无明显影响。
This article observed berberine (10mg / 1) on guinea pig ventricular papillary muscle fast response to AP, and in the use of verapamil, propranolol, respectively, after blocking the calcium channel or β-receptor, berberine papillary muscle rapid response AP The role of change. The results showed that berberine (10 mg / l) significantly prolonged the time course of fast response AP (APD 20 increased 22.90%, APD 50 increased 16.56% and APD 90 increased 13.31%). However, in the case of verapamil or propranolol, the time course of the above-mentioned berberine widening and rapid response AP disappeared completely, but in some cases APD_ (90) is still widened. The above results suggest that the widened APD effect of berberine mainly through the excitement of β-receptor to promote the influx of calcium, the last performance of fast response AP broadening of the duration. In addition, berberine potassium outflow may also have some inhibitory effect. Berberine has no obvious effect on the time and intensity curve in the range of 1-10mg / 1.