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继发性白细胞病(SL)和骨髓再生不良综合征多发生在恶性肿瘤(偶为非恶性肿瘤)化疗和/或放疗后,常带有白血病前期表现,5号和7号等染色体异常的发生率高,白血病常规药物的疗效差,生存期短。本文报告5例 SL 具有新发急性非淋巴细胞白血病(ANLL)常遇到的“特殊”染色体畸形,如 inv(16)、t(15;17)、t(8;21)和 t(9;11)。与通常的SL 患者相比,这些有“特殊”染色体异常的病人有下列特点:有实体瘤作为其原发恶性肿瘤者占4/5例;全部病例均无白血病前期,5例中仅1例出现骨髓再生
Secondary leucocythemia (SL) and myelodysplastic syndromes often occur in patients with malignant tumors (even non-malignant tumors) after chemotherapy and / or radiotherapy, often with pre-leukemia manifestations, chromosomes 5 and 7 and other chromosomal abnormalities High rate of leukemia, poor efficacy of conventional drugs, short survival. This article reports 5 cases of SL with “special” chromosomal abnormalities such as inv (16), t (15; 17), t (8; 21) and t (9; 11). These patients with “specific” chromosomal abnormalities had the following characteristics compared with the usual SL patients: 4/5 patients had solid tumors as their primary malignancy; none of the patients had pre-leukemia in all, and only 1 of 5 patients Bone marrow regeneration occurs