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北京生命科学研究所邵峰实验室近年来一直专注于研究宿主细胞质中感知细菌和病原细菌的分子免疫机制。2014年8月6日,该研究组最新的研究成果在Nature在线发表,他们发现人和小鼠的炎症性Caspase-4/5/11为胞内内毒素(Lipopolysac charide,LPS,脂多糖,俗称内毒素)的受体,直接结合LPS发生寡聚化而被激活,导致细胞炎症性坏死。在该项研究中,邵峰实验室研究人员首先建立了一个可以将LPS高效导入哺乳动物细胞内的转染
Beijing Institute of Life Sciences, Shao Feng laboratory in recent years has been focused on the host cytoplasm of the bacteria and pathogenic bacteria in the sense of molecular immune mechanisms. On August 6, 2014, the group’s latest research was published online at Nature. They found that human and mouse inflammatory caspase-4/5/11 are endotoxins (LPS, lipopolysaccharide, commonly known as Endotoxin) receptors, is directly associated with oligomerization of LPS is activated, leading to inflammatory necrosis of cells. In this study, Shao Feng laboratory researchers first established a transfection of LPS can be efficiently introduced into mammalian cells