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采用淋巴因子激活的杀伤细胞治疗妇科恶性肿瘤１４例。方法：每周输入淋巴因子激活的杀伤细胞２次，每疗程６次，平均每次输入的细胞数为２．６４×１０８。每次输注淋巴因子激活的杀伤细胞时，均在其悬液中加入１０万Ｕ白细胞介素－２。结果：２例卵巢癌腹水消失。可观察癌灶变化的６例中，１例部分有效，２例稳定，３例发展。检测治疗前后ＬＡＫ（淋巴因子激活的杀伤细胞）、ＮＫ（自然杀伤细胞）、ＣＤ４（Ｔ辅助细胞）均显著升高（Ｐ＜０．０１），ＣＤ３（总Ｔ细胞）和淋转明显升高（Ｐ＜０．０５）。８４次（１４例）输注中２６次（１１例）出现中度发热反应。１例诱发心肌梗塞。
Lymphokine-activated killer cells were used to treat 14 cases of gynecological malignancies. METHODS: Lymphokine-activated killer cells were injected twice a week for 6 cycles, with an average of 2.64 × 108 cells per input. Each time lymphocyte activated killer cells were infused, 100,000 U of interleukin-2 was added to the suspension. Results: Ascites disappeared in 2 cases of ovarian cancer. Of the 6 cases with observable lesion changes, 1 was partially effective, 2 stable, and 3 developed. LAK (lymphokine activated killer cells), NK (natural killer cells), and CD4 (T helper cells) were significantly elevated before and after treatment (P<0.01), and CD3 (total T cells) and lymphopenia were significantly increased. (P<0.05). Twenty-six (11) of the 84 (14) infusions had moderate fever. One case induced myocardial infarction.