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在体外,血和脾脏中的淋巴细胞可被IL-2激活,对某些肿瘤细胞系产生细胞毒作用。新近研究表明,这种淋巴因子激活的杀伤细胞(LAK)在一定条件下能够抑制动物和病人的实体瘤生长。Herberman及其同事总结了8个国际实验室关于LAK细胞活性的特征,认为大多数是由IL-2激活的NK细胞。LAK细胞首先由Grimm、Kosamberg及其同事报道。这种细胞与NK细胞明显不同,它能溶解对NK敏感和NK抵抗的靶细胞,尤其重要的是它能对新分离的自体或同种
In vitro, lymphocytes in blood and spleen can be activated by IL-2 and cytotoxic to some tumor cell lines. Recent studies have shown that this lymphokine-activated killer (LAK) cells can inhibit the growth of solid tumors in animals and patients under certain conditions. Herberman and colleagues summarize the characteristics of LAK cell activity in eight international laboratories and consider the majority of NK cells activated by IL-2. LAK cells were first reported by Grimm, Kosamberg and colleagues. This cell is distinctly different from NK cells in that it can lyse NK-sensitive and NK-resistant target cells, and especially importantly, it can respond to newly isolated autologous or same