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目的 :研究乙肝后肝硬化患者消化性溃疡合并出血的临床特点 ,探索小剂量心得安对肝源性溃疡并出血的疗效。方法 :肝源性溃疡并出血 43例。观察其出血方式、病变部位等临床特点 ,并随机分为治疗组 (A组 ) 2 2例 ,用心得安和泰胃美 +基础治疗 ;对照组 (B组 ) 2 1例 ,用维生素B6和泰胃美 +基础治疗 ;另外选单纯性消化性溃疡并出血 2 0例作为对照 2组 (C组 ) ,治疗方法与B组相同。结果 :肝源性溃疡以胃溃疡居多 ,合并出血时难以止血。心得安可明显缩短肝源性溃疡并出血时平均止血时间 ,较对照B组有显著差异 (P <0 .0 1) ,止血有效率亦具统计学意义(P <0 .0 5 )。结论 :肝源性溃疡以胃溃疡多见 ,合并出血时不易停止 ,可能有门静脉高压因素参与 ,小剂量心得安有助于止血。
Objective: To study the clinical features of peptic ulcer combined with hemorrhage in patients with posthepatitic cirrhosis and to explore the efficacy of low-dose propranolol on bleeding from liver-derived ulcer. Methods: Hemorrhagic liver ulcer and 43 cases. The clinical features of bleeding and lesion were observed and randomly divided into treatment group (group A) 22 cases with propranolol and Tai Weimei + basic treatment; control group (group B) 21 cases with vitamin B6 and Thai Weimei + basic treatment; another simple peptic ulcer and bleeding 20 cases as a control group 2 (C group), the same treatment and B group. Results: Hepatic ulcer mostly gastric ulcer, bleeding difficult to stop bleeding. Enco was significantly shortened bleeding and bleeding when the average time to stop bleeding, compared with the control group B were significantly different (P <0.01), hemostasis effective rate was also statistically significant (P <0.05). Conclusions: Hepatic ulcer is more common in patients with gastric ulcer. It is not easy to stop bleeding with hemorrhage. There may be portal hypertension factors involved. Small dose of propranolol helps to stop bleeding.