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目的 :观察国产格列美脲片剂对健康受试者血糖浓度的影响。方法 :40名中国健康受试者经筛选体检后进入试验 ,随机分成 8组 ,分别单次口服不同剂量格列美脲片 ,动态监测给药前 1d、给药日和给药后 1d血糖浓度 ,数据处理用SAS统计软件的单因素实验设计方差分析。结果 :格列美脲片剂 2mg至 10mg各组对中国健康受试者的血糖浓度均有不同的降低作用 ,给药日 2mg至 10mg剂量组在早晚后 2h血糖浓度较给药前 1d明显降低 (P <0 0 5 ) ;给药日 10mg剂量组午餐后 2h、晚餐后 2h、睡前 9点血糖浓度显著低于其它剂量组同一时间血糖浓度 (P <0 0 5 )。结论 :口服国产格列美脲片 2mg至 10mg均能引起健康人体血糖浓度的下降 ,效应强度可能与药物剂量有关
Objective: To observe the effect of domestic glimepiride tablets on blood glucose in healthy subjects. Methods: Forty Chinese healthy subjects were screened for physical examination and then randomly divided into 8 groups. The animals were orally given different doses of glimepiride tablets at 1 d before dosing, 1 d after dosing and 1 d after dosing Data processing with SAS statistical software univariate experimental design analysis of variance. Results: Glimepiride tablets in 2mg to 10mg groups had different effects on the blood sugar levels of Chinese healthy subjects. The 2mg to 10mg dose groups on the administration day were significantly lower than those on the 1th day before administration (P <0 05). On the administration day, the blood glucose level of the 10 mg dose group was significantly lower than that of other dose groups (P <0.05) at 2 hours after the meal, 2 hours after the dinner and 9:00 before bedtime. Conclusion: Oral administration of glimepiride tablets 2mg to 10mg can cause the blood glucose levels of healthy people to decline, the intensity of which may be related to the dose of the drug