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目的；探讨Ｐ~16基因产物在人非小细胞肺癌中的表达及其临床意义。方法：采用免疫组化法检测８３例人非小细胞肺癌组织中Ｐ~16基因产物的表达，并以２０例正常肺组织作对照。结果：肺癌中Ｐ~16表达水平（６５.９３％）明显低于正常肺组织（８８．２４％）（Ｐ＜０．０１）。Ｐ~16表达水平降低的程度与肺癌细胞分化程度，原发肿瘤大小和肺癌转移有密切关系（Ｐ＜０．０１或Ｐ＜０．０５），而与肺癌病期、组织学类型、肿瘤部位和患者年龄均无明显关系（Ｐ＞０．０５）。结论：Ｐ~16基因可能参与人非小细胞肺癌的发生、细胞的分化、发展和转移过程。
Objective To investigate the expression and clinical significance of P16 gene product in human non-small cell lung cancer. Methods: Immunohistochemistry was used to detect the expression of P 16 gene product in 83 cases of human non-small cell lung cancer, and 20 normal lung tissues were used as controls. Results: The expression level of P 16 in lung cancer (65.93%) was significantly lower than that in normal lung tissue (88.24%) (P<0.01). The decrease of P16 expression level was closely related to the differentiation of lung cancer cells, the size of primary tumors and the metastasis of lung cancer (P<0.01 or P<0.05), and it was related to the stage, histological type, tumor site of lung cancer. There was no significant relationship with the patient’s age (P>0.05). Conclusion: P 16 gene may be involved in the occurrence, differentiation, development and metastasis of human non-small cell lung cancer.