目的在4、25、37℃下研究地塞米松磷酸钠注射液和七叶皂苷钠粉针的配伍稳定性。方法将地塞米松磷酸钠注射液、七叶皂苷钠粉针按照临床用药浓度分别溶解于5%葡萄糖注射液和0.9%氯化钠注射液中,比较配制溶液后0、1、2、4、8、12h时地塞米松磷酸钠、七叶皂苷A和七叶皂苷B的含量变化、pH值、不溶性微粒数、外观。结果在4、25℃条件下,12 h内,两种药物配伍稳定性良好,在37℃时两种药物配伍稳定性较差。结论地塞米松磷酸钠注射液和七叶皂苷钠粉针溶液可以配伍使用,配伍后应于阴凉处储存,并于12 h内输注完毕。 Objective To investigate the compatibility of dexamethasone sodium phosphate injection and sodium aescinate powder at 4,25 and 37 ℃. Methods Dexamethasone sodium phosphate injection and sodium aescinate powder were respectively dissolved in 5% dextrose injection and 0.9% sodium chloride injection according to the clinical drug concentration. After 0, 1, 2, 4, Changes of dexamethasone sodium phosphate, aesculin A and aescin B at 8 and 12 h, pH value, number of insoluble particles and appearance. Results Under the conditions of 4 and 25 ℃, the stability of the two drugs was good within 12 hours. The compatibility of the two drugs was poor at 37 ℃. Conclusion Dexamethasone sodium phosphate injection and sodium aescinate powder solution can be used in combination, should be stored in the shade after compatibility, and infusion within 12 h.