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目的：研究氢醌的亚慢性毒性。方法：ＳＤ大鼠５６只，雌雄各半，随机分成４组。分别用１５ｍｇ／ｋｇ、５０ｍｇ／ｋｇ、１５０ｍｇ／ｋｇ剂量的氢醌给予灌胃染毒，每天１次，每周５天，共３个月。结果：１５０ｍｇ／ｋｇ染毒组雄性大鼠体重增长减慢，肝、肾脏器系数及雌性大鼠肝脏器系数增高，骨髓有核细胞计数降低。各染毒组雌性大鼠血红蛋白有所降低，雌、雄性大鼠血小板计数随染毒剂量升高而降低，呈明显剂量－效应关系。肝、肾及免疫功能指标无明显改变。５０ｍｇ／ｋｇ、１５０ｍｇ／ｋｇ组个别大鼠有肝细胞轻度变性。结论：氢醌主要毒作用靶器官是血液系统，对肝、肾有非特异性的损害作用。血小板计数及血红蛋白定量是氢醌的毒作用的敏感指标，亚慢性毒作用的阈剂量为５０ｍｇ／ｋｇ。
Objective: To study the subchronic toxicity of hydroquinone. Methods: Fifty-six SD rats were randomly divided into 4 groups. Respectively with 15mg / kg, 50mg / kg, 150mg / kg dose of hydroquinone given intragastric administration, once a day, 5 days a week for a total of 3 months. Results: The body weight of rats in 150 mg / kg treatment group slowed down, the coefficient of liver and kidney and the coefficient of liver in female rats increased, and the number of nucleated cells in bone marrow decreased. The hemoglobin of female rats in each exposure group decreased, and the platelet count of female and male rats decreased with the increase of exposure dose, showing a dose-effect relationship. Liver, kidney and immune function no significant change. Individual rats in the 50 mg / kg and 150 mg / kg groups had mild degeneration of hepatocytes. Conclusion: The major target organ of hydroquinone is blood system, which has non-specific damage to liver and kidney. Platelet count and hemoglobin quantification is a sensitive indicator of the toxic effects of hydroquinone, sub-chronic toxicity threshold dose of 50mg / kg.