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1972年Liebow等首先记载了淋巴瘤样肉芽肿(Lymphomatoid granulomatosis,简称LYG),其临床及组织学表现类似Wegner’s肉芽肿(简称WG)与不典型淋巴瘤。组织学特征有大量淋巴细胞、浆细胞、组织细胞及不典型淋巴—网状细胞,呈血管中心性及血管破坏性浸润坏死性肉芽肿。病变主要累及肺,其次是皮肤、神经系统及肾间质。最初发现有些LYG可转化为原始免疫细胞肉瘤或不典型淋巴瘤,认为本病可能与淋巴瘤有关,近年来随着诊断技术的进展,有的学者认为本病是一种特殊类型的恶性淋巴瘤或肿瘤前期的反应性淋巴细胞增殖。今将LYG有关问题综述如下:
In 1972, Liebow et al first described Lymphomatoid granulomatosis (LYG), which showed similar clinical and histological features as Wegner’s granuloma (WG) and atypical lymphoma. Histological features of a large number of lymphocytes, plasma cells, tissue cells and atypical lymphatic - reticular cells, showed vascular center and vascular destructive infiltration of necrotic granuloma. Lesions mainly involve the lungs, followed by the skin, the nervous system, and the renal interstitium. Initially found that some LYG can be transformed into the original immune cell sarcoma or atypical lymphoma, that the disease may be related to lymphoma, with the progress of diagnostic techniques in recent years, some scholars believe that the disease is a special type of malignant lymphoma Or pre-tumor reactive lymphocyte proliferation. The current LYG related issues are summarized as follows: