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目的 :探讨Ki- 6 7抗原在宫颈癌的表达及临床意义。方法 :应用免疫组化技术检测 15例正常宫颈上皮(normalcervicalepithelium ,NCE) ,18例宫颈上皮内瘤样病变 (cervicalintraepithelialneoplasm ,CIN)和 75例宫颈浸润癌 (invasivecarcinomaofcervix ,ICC)Ki- 6 7的表达情况。结果 :Ki- 6 7阳性染色位于细胞核。Ki- 6 7在NCE、CIN和ICC的阳性表达率分别为 13.33%、72 .2 2 %和 96 .0 0 % ,从NCE到CIN再到ICC ,Ki- 6 7阳性表达率显著升高 (P <0 .0 1)。Ki- 6 7在ICC的表达与间质浸润有关 (P <0 .0 5 ) ;而与年龄、FIGO分期、组织学分级、组织学类型、盆腔淋巴结转移和脉管浸润无关 (P >0 .0 5 )。宫颈癌突破深层间质浸润者 ,其Ki- 6 7阳性表达率显著高于浸润深度在浅层间质以内者 (P <0 .0 5 )。结论 :Ki- 6 7抗原可能在宫颈癌发生发展和间质浸润过程中起重要作用。检测Ki- 6 7抗原的表达情况对于进一步了解宫颈癌生物学行为和判断预后有一定的应用价值。
Objective: To investigate the expression of Ki- 6 7 in cervical cancer and its clinical significance. Methods: Immunohistochemical technique was used to detect the expression of 15 normal cervical epithelium (NCE), 18 cervical intraepithelial neoplasm (CIN) and 75 cervical invasive carcinoma of the cervix (ICC) Ki- . Results: Ki- 6 7 staining was located in the nucleus. The positive expression rates of Ki- 67 in NCE, CIN and ICC were 13.33%, 72.22% and 96.0% respectively, and the positive rates of Ki- 67 were significantly increased from NCE to CIN to ICC P <0 .0 1). Expression of Ki-67 in ICC was associated with interstitial infiltration (P <0.05), but not with age, FIGO stage, histological grade, histological type, pelvic lymph node metastasis and vascular invasion (P> 0. 0 5). The positive rate of Ki- 67 expression in cervical cancer which penetrated into deep interstitial infiltration was significantly higher than that in deep interstitial infiltration (P <0.05). Conclusion: Ki- 6 7 antigen may play an important role in carcinogenesis and interstitial infiltration of cervical cancer. Detection of Ki- 6 7 antigen expression for further understanding of cervical cancer biological behavior and prognosis of a certain value.