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目的分析治疗半年后梅毒甲苯胺红不加热血清试验(TRUST)滴度下降小于4倍或再升高梅毒患者的临床与脑脊液特征,探讨其TRUST滴度下降低于4倍或再升高的原因。方法对本院229例治疗半年后TRUST滴度下降小于4倍或再升高梅毒患者行腰穿进行脑脊液常规、生化、IgG指数、TRUST、梅毒螺旋体明胶凝集试验(TPPA)、荧光螺旋体抗体吸收试验(FTA-ABS)及性病研究实验室试验(VDRL)检测。结果 229例患者中有症状神经梅毒20例,无症状神经梅毒15例,HIV感染6例。结论 TRUST滴度下降小于4倍或再升高与梅毒螺旋体中枢神经系统感染有关,要及时腰穿行脑脊液检查以早期发现神经梅毒。
Objective To analyze the clinical and cerebrospinal fluid characteristics of syphilis toluidine no-heating serum test (TRUST) titer less than 4-fold or increase syphilis six months after treatment, so as to investigate the reason why the TRUST titer dropped below 4-fold or up again . Methods Nine hundred and ninety-nine patients with TRUST after six months of treatment had less than 4-fold reduction in TRUST titer or increased luteinization, and their cerebrospinal fluid routine, biochemical, IgG index, TRUST, TPPA, and fluorescent spirochete antibody absorption test (FTA-ABS) and venereal disease research laboratory test (VDRL). Results Among the 229 patients, there were 20 cases of symptomatic neurosyphilis, 15 cases of asymptomatic neurosyphilis and 6 cases of HIV infection. Conclusion TRUST titer decreased less than 4 times or increased again and Treponema pallidans central nervous system infection, to timely lumbar puncture cerebrospinal fluid to early detection of neurosyphilis.