神经纤维瘤伴发中枢神经混合性病变甚少见,现报告一例如下。患者,男,35岁,己婚,工人。因头痛、走路摇晃近两月于1986年10月18日入院。患者于1986年8月中开始自觉双额部及颞部持续性胀痛,并逐渐出现走路不稳,曾多次跌跤,间头晕,非旋转性,无耳鸣,症状日渐加重。无呕吐,无发然,食欲及大小便正常。患者自17岁起皮肤逐渐出现小结节,无痛痒,逐渐增多。否认有头部外伤及癫(疒间))史。其父及弟有类似皮肤改变,父于30 Neurofibromatosis with central nervous system mixed lesions are rare, a report is as follows. Patient, male, 35 years old, married, worker. Due to a headache, walking in the past two months on October 18, 1986 admission. In August 1986, the patient began to consciously suffer from persistent pain in both the forehead and the abdomen, and gradually became unstable. He had many falls, dizziness, non-rotation, no tinnitus, and the symptoms were getting worse. No vomiting, no hair, appetite and normal urine. Patients from the age of 17 skin gradually nodules, no itching, gradually increased. Denied the history of head trauma and epilepsy (epilepsy)). His father and brother have similar skin changes, the father of 30