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本组用放射免疫分析法对42例经脑CT检查的急性缺血性脑血管病患者血浆TXB_2及6-Keto-PGF_(1α)含量进行观察。结果表明,患者血浆TXB_2含量明显升高(p<0.01),6-Keto-PGF_(1α)含量明显降低(p<0.01)。病情重者血浆TXB_2较轻者升高明显,脑血栓形成较TIA和RIND明显升高。TXB_2变化与脑CT检查所显示之病损大小关系较为密切。病损体积愈大,TXB_2升高愈明显。患者血浆6-Keto-PGF_(1α)虽有明显降低,但与临床病情、病程及CT发现的病损大小无明显关系。本研究结果提示,患者TXB_2的变化反映了发病后脑组织的受损程度,6-Keto-PGF_(1α)的变化则可能反映了此类患者体内PGI_2合成能力减弱,与发病有关。
The group by radioimmunoassay of 42 cases of brain CT examination of acute ischemic cerebrovascular disease in patients with TXB_2 and 6-Keto-PGF_ (1α) content were observed. The results showed that the content of TXB_2 in plasma was significantly increased (p <0.01), and the content of 6-Keto-PGF_ (1α) was significantly decreased (p <0.01). Serious cases of plasma TXB_2 lighter significantly increased, cerebral thrombosis than TIA and RIND was significantly higher. The change of TXB_2 is closely related to the lesion size shown by brain CT examination. The larger the lesion volume, the more obvious TXB_2 increased. Although the plasma 6-Keto-PGF_ (1α) was significantly lower, there was no significant relationship between the level of 6-Keto-PGF_ (1α) and the clinical condition and course of disease. The results of this study suggest that the changes of TXB_2 in patients reflect the degree of brain damage after onset. The changes of 6-Keto-PGF_ (1α) may reflect the weakened capacity of PGI_2 in these patients, which is related to the pathogenesis.