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目的探讨人乳头瘤病毒(HPV)感染临床现状及其与宫颈肿瘤〔上皮内瘤变(CIN)及宫颈癌〕的关系。方法应用HPVDNA分型检测技术,对2411例妇女进行HPV检测,HPV阳性者进行阴道镜宫颈活组织检查。结果 HPV感染阳性率为16.72%(403/2411),其中高危型HPV(包括单重与多重)感染率14.06%(339/2411),低危型HPV(包括单重与多重)感染率1.62%(39/2411),高低危混合型HPV感染率1.04%(25/2411)。经病理证实,高危型HPV阳性者宫颈CINⅠ以上检出率为22.12%(75/339);低危型HPV阳性者CINⅠ1例,占低危阳性者的2.56%(1/39);高低危混合型HPV阳性者CINⅡ3例,占混合型阳性者的12.00%(3/25)。基因分型中HPV16、52、58、6、11检出率较高,依次为34.74%、14.39%、11.91%、7.69%和6.70%;且HPV16在宫颈CINⅠ以上者中检出率占70.89%(56/79)。结论 HPV亚型检测显示HPV16、52、58、6、11是主要感染亚型,HPV16是引起宫颈肿瘤的最主要亚型,进行HPV基因分型检测对宫颈肿瘤的预防、筛查和治疗均具有重要临床意义。
Objective To investigate the clinical status of human papillomavirus (HPV) infection and its relationship with cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods HPV genotyping was used to detect HPV in 2411 women, and colposcopic cervical biopsy was performed in those with HPV positive. Results The positive rate of HPV infection was 16.72% (403/2411). The infection rate of high-risk HPV (including single and multiple infection) was 14.06% (339/2411) and low-risk HPV infection (single and multiple infection) was 1.62% (39/2411), high and low risk of mixed HPV infection rate of 1.04% (25/2411). Pathologically confirmed, high-risk HPV positive cervical CIN Ⅰ detection rate was 22.12% (75/339); low-risk HPV positive CIN Ⅰ 1 cases, accounting for 2.56% (1/39) of low-risk positive; high and low risk of mixing Three cases of HPV positive CIN Ⅱ, accounting for 12.00% (3/25) of mixed positive. Genotypes HPV16,52,58,6,11 detection rate was higher, followed by 34.74%, 14.39%, 11.91%, 7.69% and 6.70%; and HPV16 cervical CIN Ⅰ in more than 70.89% (56/79). Conclusion The detection of HPV subtype HPV16,52,58,6,11 is the main subtypes of infection, HPV16 is the most important subtype of cervical cancer, HPV genotyping detection of cervical cancer prevention, screening and treatment have Important clinical significance.