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Mifepristone(RU486)是具有很强的抗孕前的和抗糖皮质激素性质的合成类固醇,是对怀孕早期进行流产的有效的医疗措施。因孕激素对植入至关重要,研究者们测试Mifepristone用于性交后紧急避孕的效果。研究者们研究了72小时内无保护的性交而要求紧急避孕的800名妇女和青少年。共有398名妇女和青少年随机给予100μg乙炔雌二醇和1mg 18-甲炔诺酮,每人给药2次,间隔12小时(传统治疗方法),402名妇女及青少
Mifepristone (RU486) is a potent anti-progestational and anti-glucocorticoid-like synthetic steroid and an effective medical treatment for abortion in early pregnancy. Because progestin is essential for engraftment, researchers test the effect of Mifepristone on emergency contraception after sexual intercourse. Researchers studied 800 women and adolescents who required emergency contraception within 72 hours of unprotected intercourse. A total of 398 women and adolescents were randomized to receive 100 μg of ethinyl estradiol and 1 mg of 18-norethindrone twice daily for 12 hours (traditional treatment), 402 women and adolescents