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目的探讨儿童结核性脑膜炎临床特征与卡介苗(BCG)接种之间的关系。方法将重庆医科大学附属儿童医院2004—2007年122例儿童结核性脑膜炎按是否接种BCG分为BCG组(54例)和未接种BCG组(68例),对临床资料进行回顾性分析。结果0～5岁为发病高峰(67.2%);以农村患儿为主(72.1%);临床分期以中晚期为主,其中未接种BCG组的晚期发病例数明显高于BCG组,差异有统计学意义(P<0.05);BCG组临床预后明显好于未接种BCG组,差异有统计学意义(P<0.05);两组在临床特征及是否发生脑积水方面差异无统计学意义(P>0.05)。结论BCG组晚期结核性脑膜炎的发生率较未接种BCG组低,并且其预后好于未接种BCG组。
Objective To investigate the relationship between the clinical features of tuberculosis meningitis in children and BCG vaccination. Methods A total of 122 children with tuberculous meningitis from Children’s Hospital of Chongqing Medical University from 2004 to 2007 were divided into BCG group (54 cases) and non-BCG group (68 cases) according to BCG vaccination. The clinical data were retrospectively analyzed. Results The highest incidence was found in 0-5 years old (67.2%), mainly in rural children (72.1%). The clinical stage was mainly in the middle and late stages. The incidence of late-onset BCG group was significantly higher than that of BCG group (P <0.05). The clinical prognosis of BCG group was significantly better than that of BCG group, the difference was statistically significant (P <0.05). There was no significant difference in clinical features and whether there was hydrocephalus P> 0.05). Conclusions The incidence of advanced tuberculous meningitis in BCG group is lower than that in non-BCG group, and its prognosis is better than that in non-BCG group.