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氯灭酸[N-(间氯苯基)-邻氨基苯甲酸]是我国首先合成并筛选出来的解热消炎镇痛药,临床效果较好,但有不少副作用.近年来的无机药物研究表明,金属配合物与人体的关系十分密切.我们曾制出十六种氯灭酸的稀土盐,其毒性比相应的氯化物小.其他金属的氯灭酸盐尚未见报道.本文在水中以氯灭酸钠(以NaA表示)与Mg(Ⅱ),Ca(Ⅱ),Sr(Ⅱ),Ba(Ⅱ),In(Ⅱ),Tl(I),Mn(Ⅱ),Fe(Ⅲ),Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ),Ag(Ⅰ),Cd(Ⅱ),Pb(Ⅱ)等金属离子制备出十五种氯灭酸金属盐,测定了它们的化学组成,UV,IR,摩尔电导率及热谱,其结果汇总于表1及表2.
Chloramphenicol [N- (m-chlorophenyl) - anthranilic acid] is China’s first synthesis and screening antipyretic anti-inflammatory analgesic, the clinical effect is better, but there are many side effects.In recent years, the study of inorganic drugs The results show that the metal complexes have very close relationship with the human body.We have made 16 rare earth salts of chlorhexorphan and its toxicity is less than that of the corresponding chlorides.The other chlorides of the metal have not been reported.In this paper, Sodium chloroformate (expressed as NaA) and Mg (Ⅱ), Ca (Ⅱ), Sr (Ⅱ), Ba (Ⅱ), In (Ⅱ), Tl (I) Fifteen chlorfenamic acid metal salts were prepared from metal ions such as Co (Ⅱ), Ni (Ⅱ), Cu (Ⅱ), Zn (Ⅱ), Ag (Ⅰ), Cd (Ⅱ) and Pb (Ⅱ) Their chemical composition, UV, IR, molar conductivity and thermal spectra, the results are summarized in Table 1 and Table 2.