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1971年,英国的约翰·迈特博士提出阿司匹林类药物的作用机理是抑制前列腺素生物合成。从那时起,人们对这组不同抑制剂与被药学家称为环加氧酶(COX)的酶之间的相互作用发生了浓厚的兴趣。环加氧酶有两种异构体:COX-1和COX-2,用COX-1酶筛选的药物现已有几种新药上市了。如今,该领域的研究又注入了新的活力。人们测定出了COX-1(其术语为PGHS-1,即前列腺素H2合成酶-1)的三维结构。该结构的清晰度尽管较低,但无疑是正确的。该结构还指示这种酶在细胞膜上呈单极状态分布(也
In 1971, British Dr. John Matt suggested that the mechanism of action of aspirin drugs is to inhibit prostaglandin biosynthesis. Since then there has been a great deal of interest in the interaction between this group of different inhibitors and the enzymes that physicians call cyclooxygenase (COX). There are two isoforms of cyclooxygenase: COX-1 and COX-2. Several new drugs are now available for selection with COX-1 enzyme. Nowadays, research in this field has reinvigorated the vitality. The three-dimensional structure of COX-1 (the term PGHS-1, prostaglandin H2 synthase-1) has been determined. The clarity of the structure, though lower, is undoubtedly correct. This structure also indicates that this enzyme is monopolarly distributed on the cell membrane (also