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目的 :观察 β 受体阻滞剂倍他乐克对不稳定型心绞痛患者心率变异性 (HRV)的影响。方法 :将不稳定型心绞痛患者(UAP) 84例随时机分为两组 :倍他乐克组 44例 ,对照组 40例 ,两组均接受消心痛或鲁南心康片扩管 ,阿期匹林抗凝 ,含镁激化液处理 ,用药两周后行三通道动态心电图检查 ,观察两组患者HRV的时域指标 :2 4小时连续正常R -R间期标准差 (SDNN) ,2 4小时内连续 5min节段的平均正常的R -R间期标准差 (SDANN ) ,2 4小时内连续 5min节段的平均正常的R -R间期标准差平均数(SDNNindex) ,2 4小时内连续正常的R -R间期差值均方的平方根 (RMSSD) ,相邻R -R间期差值大于 5 0ms心搏数占所有分析信息期内心搏数的百分比 (PNN50 )。结果 :倍他乐克组HRV中反映交感神经张力各项指标较对照组明显延长 (P <0 0 1) ,而反映迷走神经张力的各项指标与对照组无显著差异 (P >0 0 5 )。结论 :行 β 受体阻滞剂倍他乐克干预的不稳定型心绞痛患者HRV升高 ,增加心律的变异范围 ,在不稳定型心绞痛患者应用 β 受体阻滞剂是有益的。
Objective: To observe the effect of beta-blocker betametabol on heart rate variability (HRV) in patients with unstable angina pectoris. Methods: Eighty-four patients with unstable angina pectoris (UAP) were randomly divided into two groups: methotrexate group (44 cases) and control group (40 cases) After two weeks of treatment, three-channel Holter examination was performed. The time-domain indexes of HRV in two groups were observed: 24-hour continuous normal R-R standard deviation (SDNN), continuous 5 min Mean normal R-R interval standard deviation (SDANN) of the segments, average normal R-Rs standard deviation mean (SDNN index) of the segments for 5 min in 4 hours, continuous normal R R interval between the mean square root mean square (RMSSD), the difference between the adjacent R -R interval is greater than 5 0ms heartbeat percentage of heart rate (PNN50) during the period of all the analysis information. Results: The indexes reflecting sympathetic tone in HRV group were significantly longer than those in control group (P <0.01), while the indexes reflecting vagal tone were not significantly different from those in control group (P> 0.05) . CONCLUSION: Elevated HRV in patients with unstable angina pectoris treated with beta-blocker beta-sheet increases the range of variation in cardiac rhythm and may be beneficial in patients with unstable angina pectoris.