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目的:观察痛泻要方联合匹维溴铵治疗腹泻型肠易激综合征(IBS)的临床疗效及对外周血5-HT、NPY水平的影响。方法:将90例腹泻型肠易激综合征(肝郁脾虚)患者随机分为对照组46例与观察组44例,对照组患者采用匹维溴铵治疗,观察组患者加用痛泻要方,4周为1个疗程,观察两组患者治疗前后腹痛、腹泻次数、大便性状等症状积分及血液中5-羟色胺(5-HT)、酪神经肽(NPY)水平改善情况,并比较临床疗效。结果:治疗后,两组患者腹痛、腹泻次数、大便性状改变等症状积分均降低,且观察组改善更明显(P<0.05);两组患者5-HT水平降低,NPY升高,且观察组改善更明显(P<0.05);观察组患者治疗总有效率为93.18%,明显高于对照组的73.91%,差异具有统计学意义(P<0.05)。结论:痛泻要方联合匹维溴铵治疗腹泻型IBS疗效明显,可更好地改善胃肠激素及5-HT水平,值得临床推广应用。
Objective: To observe the clinical efficacy of Tongxie Yaofang combined with pinaverium bromide in the treatment of diarrhea-predominant irritable bowel syndrome (IBS) and the effect on the level of 5-HT and NPY in peripheral blood. Methods: 90 cases of diarrhea-predominant irritable bowel syndrome (liver depression and spleen deficiency) were randomly divided into control group (46 cases) and observation group (44 cases). Patients in the control group were treated with pinaverium bromide. Patients in observation group , 4 weeks as a course of treatment. The scores of abdominal pain, diarrhea, stool and other symptoms and the improvement of 5-HT and NPY in the two groups were observed before and after treatment. The clinical curative effect was compared . Results: After treatment, the scores of abdominal pain, diarrhea and changes of stool traits decreased in both groups, and the improvement in the observation group was more obvious (P <0.05). The levels of 5-HT and NPY in both groups were significantly decreased (P <0.05). The total effective rate of the observation group was 93.18%, which was significantly higher than that of the control group (73.91%), the difference was statistically significant (P <0.05). Conclusion: Tong Xie Yao Fang combined with pinaverium bromide treatment of diarrhea IBS obvious effect, can better improve gastrointestinal hormones and 5-HT levels, worthy of clinical application.