近30年来,利尿药物的应用有了很大的进展,许多新型利尿剂先后问世,但由于各类利尿剂的作用点不同,临床运用有很大差异,如盲目使用,不仅无效,且可导致内环境紊乱而加重病情。本文就利尿药物的临床运用选择作一概述,供参考。 1.有机汞利尿剂为最早的利尿剂,1919年希腊有一细心的护士在对一位先天性梅毒病人服用汞剂记录尿量时发现尿量增多,而引起医学界重视,后经研究是一种强效的利尿剂。主要作用于髓袢升支厚段,抑制该部氯泵对氯的主动转运,从而减少钠的被动重吸收。临床上用于心源性及肝源性水肿,但由于毒性大并有其他更好的利尿药物所代替,故现摒弃。 In the recent 30 years, great progress has been made in the application of diuretic drugs. Many new diuretics have come out in succession. However, due to the different points of action of various diuretics, there are great differences in clinical application. For example, blind use is not only ineffective, Internal environment disorders and aggravate the condition. This article on the clinical use of diuretic drugs choose to make an overview for reference. 1. Organic mercury diuretics as the earliest diuretic, Greece in 1919 a careful nurse in a congenital syphilis patients taking amalgam urine volume was found when the urine output increased, which attracted the attention of the medical profession, after the study is a A potent diuretic. The main role in the thickening of the medullary 支 branch, inhibiting the Department of chlorine pump active transport of chlorine, thereby reducing the passive sodium reabsorption. Clinically used for cardiogenic and liver-derived edema, but because of the toxicity and other better diuretic drugs replaced, it is now abandoned.