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从库的排列和组合技巧得到活性化合物的结构信息,应用编码技术标记库化合物的结构以及对活性化合物直接进行结构分析。阐述了组合库的筛选及其在新药应用领域的研究进展。简要介绍了作者在组合化学方面所做的研究工作。
Structure information of the active compounds is obtained from the permutations and combinatorial techniques of the libraries, the structure of the library compounds labeled with coding technology and the direct structural analysis of the active compounds. The screening of combinatorial libraries and its research progress in the field of new drug application are described. This article briefly introduces the author’s research work on combinatorial chemistry.