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在20世纪60年代人们就发现了降钙素基因相关肽超家族,它最初包括5个成员:降钙素(CT),胰岛淀粉样多肽(IAPP),两种降钙素基因相关肽(CGRP)和肾上腺髓质素(ADM)[1],这些肽类激素在不同的器官和组织调节人体的动态平衡,发挥重要作用。2004年,研究人员又发现了CGRP超家族的新成员中介素(intermedin,IMD),因为人类的前体ADM和前体IMD的氨基酸和核苷酸序列几乎一致,而且在功能上具有一定相似性,所以有人也称其为ADM2[2]。本文将从中介素的生物学特性,分布与受体,以及各系统的中介素相关最新研究进展方面展开综述如下。
In the 1960s people discovered the superfamily of calcitonin gene-related peptides, which originally comprised five members: calcitonin (CT), amylin (IAPP), two calcitonin gene-related peptides (CGRP ) And adrenomedullin (ADM) [1], these peptide hormones in different organs and tissues to regulate the body’s dynamic balance, play an important role. In 2004, researchers also discovered a new member of the CGRP superfamily, intermedin (IMD), because the amino acid and nucleotide sequences of human precursor and precursor IMDs are nearly identical and have some similarity in function So, some people call it ADM2 [2]. This article reviews the recent advances in the studies on the biological properties, distribution and receptors of intercalators, and the intervening agents of each system.