在抑癌基因中 ,p5 3与肿瘤的关系较早受到人们的重视 ,而且是迄今研究的最为广泛、最为系统的抗癌基因之一。本文论述 p5 3基因的结构与蛋白的功能 ,以及 p5 3基因的几个多态性位点。就近年来 p5 3基因的多态性与散发性和遗传性卵巢癌的相关研究做一简要综述 ,并对以后 p5 3基因多态性的研究方向提出一些建议。 Among the tumor suppressor genes, the relationship between p5 3 and tumor has been paid more attention by people earlier, and it is one of the most extensively studied and most systematic anti-oncogenes studied so far. This article discusses the structure and function of the p5 3 gene and several polymorphic sites of the p5 3 gene. In recent years, the polymorphism of p5 3 gene and sporadic and hereditary ovarian cancer related research to make a brief review, and future p5 3 gene polymorphism in the direction of research put forward some suggestions.