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Acute myeloid leukemia (AML) is a rather common disease,which is characterized by proliferation of impaired-function hematopoietic progenitor cells.In tradition standpoint,AML had been considered a genetic-alteration disease,but more and more experimental evidence showed that epigenetic modifications would play an important role in the development and maintenance of leukemia cells.In this article,we summarized the relationship of epigenetic alterations and acute myeloid leukemia.